A clinical review published on PubMed demonstrates that miR-140 heavily dictates how sensitive cancer cells are to chemotherapy drugs like doxorubicin, cisplatin, and temozolomide. Up-regulating its expression can actively enhance the efficacy of these treatments.
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A breakthrough study published in Nature discovered that a "gain-of-function" mutation in the miR-140 gene leads to a severe, novel autosomal dominant human skeletal dysplasia. 🔬 Function in Cancer and Therapeutics A clinical review published on PubMed demonstrates that
Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix. A breakthrough study published in Nature discovered that
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MicroRNA-140 is highly expressed in cartilage and is a master regulator of chondrocytes (the cells responsible for cartilage formation).