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RARα is essential for maintaining the balance of the gut. A lack of RARα signaling in intestinal cells can lead to: 21703.rar
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: This specific subtype is characterized by the fusion protein PML-RARα . New therapies focus on blocking other factors, like HIF-1α, which cooperate with this fusion protein to drive leukemia progression. New therapies focus on blocking other factors, like
: An overproduction of goblet and Paneth cells, which can disrupt normal gut function.
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: Novel agonists like SY-1425 (tamibarotene) are being developed to selectively inhibit the growth of tumor cells that rely on high RARα expression. 3. Cellular Reprogramming
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