Researchers using X-ray powder diffraction (XRPD) and thermal analysis have identified three primary forms:
: This conversion occurs through moderate heating (approximately 200 °C ) under vacuum. 54757.rar
: Form I can be quantitatively converted into Form II. 54757.rar
Acitretin is a second-generation retinoid and a metabolite of etretinate. While effective for severe psoriasis, its physical properties are highly dependent on the crystallization process. Because different crystalline structures (polymorphs) can change the drug’s solubility and shelf-life, precise characterization is essential for regulatory compliance and patient safety ( ResearchGate ). 2. Characterization of Polymorphic Forms 54757.rar