Buying Bitcoin directly with an prepaid card is tricky because major exchanges like Coinbase and CEX.IO generally do not support American Express or prepaid cards for direct crypto purchases.

Are you looking to use the at an ATM, or are you hoping to do a Serve-to-Serve transfer to someone online?

You will almost always need to complete a Know Your Customer (KYC) check, which involves providing a photo of your ID.

However, you can still use your Amex Serve card through or certain mobile apps: 1. Paxful (P2P Marketplace)

Try linking your Amex Serve card as a debit card in the Cash App settings. If accepted, you can use those funds to buy Bitcoin directly within the app.

Fees on P2P platforms for prepaid cards can be very high, sometimes up to 30% above market price. 2. Cash App (US Only)

Search for sellers who accept "American Express Serve" or "Amex Serve to Serve" transfers.