: Enlarged fluid spaces in the deep white matter.
The v2.0 criteria significantly increase diagnostic sensitivity—capturing more true cases without losing specificity—by broadening the biological markers recognized by MRI. : Enlarged fluid spaces in the deep white matter
: Specific patterns of white matter damage. Clinical Significance A diagnosis of probable CAA can now be
The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria : Enlarged fluid spaces in the deep white matter
The Boston criteria version 2.0 for cerebral amyloid angiopathy
: For the first time, white matter characteristics are part of the formal criteria. A diagnosis of probable CAA can now be made with just one lobar hemorrhagic lesion if accompanied by either:
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