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MH is usually inherited in an autosomal dominant pattern, often involving mutations in the gene. Malignant Hyperthermia
Malignant hyperthermia (MH), or hyperthermie maligne , is a life-threatening pharmacogenetic disorder triggered primarily by volatile anesthetic gases and the muscle relaxant succinylcholine. It results in a hypermetabolic crisis due to an uncontrolled release of calcium from skeletal muscle cells. While rare, affecting roughly 1 in 5,000 to 1 in 50,000 anesthesia cases, it requires immediate recognition and treatment with dantrolene to prevent fatal complications. Download HYPERTHERMIE MALIGNE pptx