Hem#265 Rar -
The chimera is constructed by fusing the ligand-binding domain of the retinoic acid receptor (RAR) to a reporter sequence that allows tracking (e.g., green fluorescent protein).
The GR-RAR chimera is a powerful tool for discovering novel RAR ligands and analogues. It improves upon standard assays that exclusively measure gene activation potential, as this system visualizes the receptor's subcellular trafficking. This technique offers significant advantages in studies exploring ligand-induced receptor dynamics. 5. Conclusion Hem#265 rar
Development and Application of a Glucocorticoid/Retinoic Acid Receptor (GR-RAR) Chimera for In Vivo Translocation Assays The chimera is constructed by fusing the ligand-binding
Marine-Derived Bioactive Ingredients in Functional Foods for Aging allowing for kinetic studies.
The translocation from cytoplasm to nucleus is observable in living cells, allowing for kinetic studies.
