: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend.
: House is motivated by an unfamiliar sense of guilt. He ponders the unfairness of a "misanthropic drug addict" surviving while a promising young physician dies. [S4E16] House's Head (Part 2)
: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning. : House’s subconscious manifests a guide who prompts
: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure He ponders the unfairness of a "misanthropic drug
: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes