: While biologically human (conceived in the Time Vortex), medical scans in this episode suggest River may have two hearts , mirroring Time Lord physiology. Episode Significance River Song | Tardis - Doctor Who Wiki

: Amy and Rory's childhood friend Mels is revealed to be their daughter, Melody Pond . After being shot by Hitler (who is promptly shoved into a cupboard), Mels regenerates for the first time on-screen, becoming the woman known as River Song .

: It is revealed that the TARDIS itself taught River how to pilot it, which explains why she is often more proficient than the Doctor.