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Inside the cell, TG2 contributes to survival pathways. However, its dysregulation is linked to celiac disease, fibrosis, and tumor progression, making it a critical player in disease research.
Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats: Inside the cell, TG2 contributes to survival pathways
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🔬 TG2: The Molecular "Swiss Army Knife" Shaping Cellular Fate Meet —one of the most versatile enzymes in the human body
TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing.
Ever wonder how your cells manage to survive, remodel tissue, or even respond to injury? Meet —one of the most versatile enzymes in the human body.
Because TG2 is implicated in chronic conditions like cancer and neurodegeneration (such as Huntington's and Alzheimer's), it is now a hot target for new therapeutic drugs designed to selectively inhibit its activity without harming healthy cells.
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